Greetings. I played SMBX2b4 on Linux Mint 19.3 using Wine Staging 5.5 and ran into a major and a minor issue.
The major issue is that when attempting to use Teleportation Pipes, such as those found in the World Maps of "Super RMN All-Stars" and "Yoshi's Archipelago", the following happens:
This does not occur on version 184.108.40.206.
The minor issue, also shown in the video, is that the game displays the "Controller Battery Empty" message, even though I use a wired Xinput controller.
Running the game via lutris-5.5-2-x86_64 solved neither of these.
EDIT: The Pipe Error only happens when using the controller. Entering with the Z key works fine.